Alcohol elimination from the body more than 90 of the absorbed alcohol is broken down and eliminated by the liver up to 5 is removed from the body by breath up to 5 by urine and only negligible amounts by the stool and sweat 17the breakdown of alcohol by the enzyme gastric alcohol dehydrogenase in the stomach is probably negligible 181920. Alcohol metabolism general principles 1 9 list 3 describes some general principles of alcohol metabolism the major enzyme systems responsible for the oxidation of ethanol alcohol dehydrogenase and to a lesser extent the cytochrome p450 dependent ethanol oxidizing system are present to the largest extent in the liver. Alcohol absorption distribution elimination alcohol is eliminated from the body by excretion and metabolism most alcohol is metabolized or burned in a manner similar to food yielding carbon dioxide and water a small portion of alcohol is excreted such as through the breath leaving the body as alcohol unchanged . Metabolism and excretion the metabolism and elimination parameters of alcohol are more consistent than the absorption and distribution 9 a small proportion 2 5 of the alcohol absorbed is excreted unchanged in the urine sweat or breath 5 2 but the majority 90 is removed via oxidation by adh 10 2 this can occur. Overview how is alcohol metabolized by the body samir zakhari phd s amir z akhari p hd is director division of metabolism and health effects national institute on alcohol abuse and alcoholism bethesda maryland alcohol is eliminated from the body by various metabolic mechanisms the primary enzymes involved
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