Monoamine oxidase inhibitors maois are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes monoamine oxidase a mao a and monoamine oxidase b mao b they are best known as powerful anti depressants as well as effective therapeutic agents for panic disorder and social phobia. Get this from a library monoamine oxidase and disease prospects for therapy with reversible inhibitors keith f tipton p dostert m strolin benedetti centre de recherche delalande. Reversible monoamine oxidase inhibitor antidepressants rimas work by reducing the activity of monoamine oxidase which is a chemical found throughout the body monoamine oxidase breaks down noradrenaline also called norepinephrine and serotonin and other chemicals made and used by the body and brain these chemicals are important in emotions . An enzyme called monoamine oxidase is involved in removing the neurotransmitters norepinephrine serotonin and dopamine from the brain maois prevent this from happening which makes more of these brain chemicals available to effect changes in both cells and circuits that have been impacted by depression maois also affect other neurotransmitters in the brain and digestive system causing . Berlin i zimmer r thiede hm payan c hergueta t robin l et al comparison of the monoamine oxidase inhibiting properties of two reversible and selective monoamine oxidase a inhibitors moclobemide and toloxatone and assessment of their effect on psychometric performance in healthy subjects br j clin pharmacol 1990 30805 816
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